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Although, there are several things to consider when looking at health, the sign on the cusp of the 6th house will often indicate a part of the body that may eventually cause serious health issues, although it does not always indicate the cause of one's demise. Planets in that house will also give clues according to the rule of correspondences. For instance, both Jupiter and Sagittarius rule liver ailments, etc. See Astrology and the Body.