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The Moon in the Twelfth House can indicate traumas early in life. The mother was probably subjected to suffering or involved with the care of those who suffered. People with the Moon in this house need to feel their sacrifices are not in vain. There can be intense emotional pain with this placement, but this leads to an extraordinary gift for empathising with the pain of others. In the home, they will need a retreat or meditation room where they can be alone with their thoughts.
caqn you comment further if moon is the lord of the ascendent, what other ramifications may take place.